Calendario degli Esami
Le date degli esami di profitto per i vari corsi di insegnamento della Genetica Medica

1/1/1970 - 1/1/1970


(° anno - ° semestre)
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Orari delle Lezioni
La raccolta degli orari delle lezioni per i diversi Corsi di Insegnamento
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I nostri Sponsor
I partner tecnologici del Laboratorio di Genetica Medica - PTV  
 
 

Genetica Medica: Area Ricerca

Il laboratorio di Genetica Medica dell’Università di Roma “Tor Vergata” si occupa prevalentemente di tematiche di Genetica biochimica, Genetica umana, Citogenetica, Genetica medica e Genetica molecolare. Il laboratorio di Genetica Medica ha contribuito al clonaggio di nuovi geni, alla caratterizzazione di nuove mutazioni, allo studio dell’espressione e alla messa a punto di metodo originali per la diagnosi prenatale e postnatale. Negli ultimi anni le nostre ricerche si sono focalizzate su studi di genomica e analisi multigenica con particolare riferimento alla psoriasi, alle cardiopatie congenite, alle malattie cardiovascolari, alla distrofia miotonica, alla fibrosi cistica. Inoltre abbiamo messo a punto metodi innovativi di terapia genica e sviluppato test genetici orginali basati su microarray genomici e di espressione. Di interesse è la scoperta delle basi molecolari della sindrome Displasia Mandibulo-Acrale (MAD) e l’identificazione di una nuova isoforma del recettore OxLDL importante nella suscettibilità genetica all’infarto del miocardio.
 
 
The Medical Genetics Laboratory at “Tor Vergata” University in Rome is involved in many research projects spanning from Molecular Genetics to Cytogenetics, Human and Medical Genetics.
 
1. Interdisciplinary research into:
 
  • Human genetics
• Medical Genetics
• Genomics
• Molecular genetics and others
 
 
2. Translational research into:
 
  • Molecular diagnosis
• Presymptomatic and predictive diagnosis
• Prenatal diagnosis
• Pharmacogenetics and others
 
 
3. Leadership in the
 
  • Molecular and Medical Genetics
• MD/PhD Graduate Programs at Tor Vergata University of Rome
 
 
4. Interest in
 
  • Genomic analysis of significant public health problems
• Genomic analyses of humankind
• Gene/environment interactions
• Functional analysis of SNPs (single nucleotide polymorphisms)
• Molecular Genetics of Rare diseases
 
 
 
 
 
Research Projects Ongoing or Completed During the Last 3 Years:
 
  • 1998-2001 Italian National Council of Research "Analysis of RNAs transcribed from SMN1 for the diagnosis of spinal muscular atrophy". This project studied an original method to identify SMA heterozygous patients. As part of this project we developed a method that has been patented (MI2000A 002041 19.09.2000).
  • 2000 Italian Telethon: "Psoriasis genetics" This project has allowed the identification of a novel psoriasis susceptibility gene on chromosome 1 and established a model to study the interaction between genes in a complex disease.
  • 1999 SMA families, USA "Defining a role for SMN and NAIP as possible inhibitors of neuronal .
  • 2000-2002 Italian Ministry of Research and Technology (MURST). "Multifocal combined approaches for gene therapy of malignant gliomas". This is a multicenter project involving different groups. Our group is involved in studying the expression of VEGF gene and its receptor before and after directed in vitro mutagenesis.
  • 2001 Italian Ministry of University, Research and Technology “ Genetic basis of congenital heart diseases using a gene-expression profiling approach”.
  • 2000-2002 “Genetics of complex diseases: molecular methods, mathematical analyses, and some applications". The purpose of this project is the analysis of genes from the Epidermal Differentiation Complex (EDC), searching for psoriasis alleles. In particular we examined at expression level simultaneously 12 different genes expressed in human keratinocytes.
  • 2002-2004: “Genetics and Genomics of Atherosclerosis” Italian Ministry of University and Research.
  • 2002-2004: ”Dissecting mendelian phenotypes” Italian Ministry of University and Research (Fondi FIRB).
  • 2002-2004: “Operative network on Neuromuscular Disorders”, Italian Ministry of Health.
  • 2002-2004:” Neurogenetics of neurodegenerative Disorders” Italian Ministry of Health.
  • 2002-2004: “ Research of cystic fibrosis phenotype modifier genes” Italian Ministry of Education, University and Research.
  • 2003- 2005: “MAD and laminophaties” Italian Telethon.
  • 2005-2009: EU Grant NACBO “Novel and improved nanomaterials, chemistries and apparatus for nanobiotechnology”.
  • 2005-2007: AIRC (Italian Association for Cancer Research) “Genomics of Human Prostate Cancer”.
  • 2004-2007: Genetics of Cystic Fibrosis. Regione Lazio, Italy.
  • 2005-2008: EU Grant FP6-2004-LIFESCIHEALTH-5: Nuclear Envelope-linked Rare Human Diseases: From Molecular Pathophysiology towards Clinical